Compare the Best Weight Loss Injections

FDA-approved weight loss injections like Wegovy®, Zepbound®, and Saxenda® are typically indicated for adults with a BMI of 30 or higher (obesity) or those with a BMI of 27+ who have at least one weight-related health condition such as type 2 diabetes, high blood pressure, or high cholesterol. A healthcare provider will evaluate your complete medical history, current medications, and overall health to determine if these treatments are appropriate for you.

Zepbound® (tirzepatide) is a dual GIP and GLP-1 receptor agonist, while Wegovy® (semaglutide) works only on GLP-1 receptors. Both are FDA-approved specifically for chronic weight management and are administered as weekly injections. In clinical trials, participants taking Zepbound showed higher average weight loss compared to those taking Wegovy, though individual results vary significantly. Your healthcare provider can help determine which medication may be more appropriate based on your specific health profile and goals.

No. Ozempic® is FDA-approved for the treatment of type 2 diabetes mellitus and to reduce cardiovascular risk in adults with type 2 diabetes and established cardiovascular disease—NOT for weight loss.While patients taking Ozempic may experience weight loss as a side effect, it is not indicated for this use. Wegovy® contains the same active ingredient (semaglutide) at a higher dose and IS FDA-approved for chronic weight management. If weight loss is your primary goal, speak with your healthcare provider about FDA-approved options like Wegovy®, Zepbound®, or Saxenda®.

All GLP-1 receptor agonists carry aBoxed Warning for thyroid C-cell tumors. These medications are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Other serious risks include acute pancreatitis, acute kidney injury, gallbladder disease, severe gastrointestinal reactions, hypersensitivity reactions, diabetic retinopathy complications (in patients with diabetes), and suicidal behavior and ideation. Common side effects include nausea, vomiting, diarrhea, constipation, and stomach pain. Consult your healthcare provider and review the full prescribing information for complete safety details.

Weight loss injections are typically intended for long-term use in combination with a reduced-calorie diet and increased physical activity. Research indicates that weight regain is common after discontinuing GLP-1 medications. Many healthcare providers recommend ongoing treatment for weight maintenance, though the appropriate duration should be determined by your healthcare provider based on your individual response, health status, and treatment goals.

Insurance coverage for weight loss medications varies significantly by plan. Many plans historically have not covered obesity medications, though coverage is expanding as clinical evidence grows. Some telehealth providers offer cash-pay options, and manufacturers may offer savings programs for eligible patients. Contact your insurance provider directly to understand your specific coverage, and ask about any patient assistance programs that may be available.

Yes, many licensed telehealth platforms now offer consultations for weight loss medications. A licensed healthcare provider will conduct a virtual evaluation to determine if you’re an appropriate candidate. If prescribed, medications can often be shipped directly to your home. Be cautious of providers offering compounded GLP-1 medications—these are not FDA-approved and have not been evaluated for safety, effectiveness, or quality. Always verify that you’re working with a licensed provider prescribing FDA-approved medications.